Medicef

Indication:

Medicef (Cefradine) is indicated for the treatment of the following infections when caused by susceptible organisms: 
The upper and lower respiratory tract infections: Pharyngitis, sinusitis, otitis media, tonsillitis, laryngo-tracheo-bronchitis, acute and chronic bronchitis, lobar and chronic bronchopneumonia.

Urinary tract infections: Cystitis, urethritis, pyelonephritis. 

Skin and soft tissue infections: abscess, cellulitis, furunculosis and impetigo. 

Surgical prophylaxis: Surgical procedures associated with high risk of disastrous consequences of infections. Medicef is also of value where postoperative infections would be disastrous and where patients have a reduced host resistance to bacterial infection. Protection is best ensured by achieving adequate local tissue concentrations at the time when contaminations are likely to occur. Thus, Medicef should be administered immediately prior to surgery and continued during the postoperative period. 

 

Dosage & Administration:

Medicef may be given regardless of meal.

Adults
Oral: The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe and chronic infection, the dose can be increased upto 4 gm daily which should be given in equally divided doses.
In skin and skin structure infections and respiratory tract infections: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
In Lobar pneumonia: Usual dose is 500 mg every 6 hours or 1g every 12 hours.
In uncomplicated urinary tract infections: Usual dose is 500 mg every 12 hours. In more serious urinary tract infections including prostatitis, 500 mg every 6 hours or 1 g every 12 hours may be administered.

Children 
Oral: The usual dose is 25-50 mg/kg/day total, given in 2 or 4 equally divided doses. For otitis media daily dose from 75-100 mg/kg body wt. in divided doses every 6 to 12 hours are recommended. Dose may be increased up to 4 g/day depending on the severity of the infection.

Elderly
There are no specific dosage recommendations or precautions for use in the elderly except as with other drugs to monitor those patients with impaired renal or hepatic functions.

Dosage in renal impairment
A modified dosage schedule is necessary in patients with decreased renal function. Each patient should be considered individually. The following modified dosage schedule is recommended as a guideline, based on creatinine clearance. In adults, the initial loading dose is 750 mg of Cephradine and the maintenance dose is 500 mg at the following intervals:

Preparation:

Medicef 500 Capsule: Each capsule contains Cephradine USP 500 mg.

Medicef Dry Powder: Each 5 ml suspension contains Cephradine USP 125 mg.