Bactocycline

Indication:

Tetracycline (Bactocycline) is the drug of choice in the following infections:

1. Ricketsial infection (Rocky Mountain spotted fever, endemic and scrub typhus fever and human ehrlichiosis).

2. Mycoplasma pneumoniae infections in adults. Outbreaks of pneumonia caused by this organism are common in barracks and institutions. Most cases occur in children and young adults. Maculopapular rashes, haemolytic anaemia and meningo-encephalitis occur rarely.

Tetracycline

3. Chlamydial Infections - Chlamydia psittaci: This organism is the cause of psittacosis (ornithosis), a systemic illness contracted from infected birds. The pneumonia associated with it may be extensive, and severe systemic upset and death are common.Headache is a prominent earlysymptom.

4. Non-gonococcal or non specific urethritis: Inflammation of the urethra not resulting from gonococcal, chlamydial, or other specific infectious agents.

5. Lyme disease

6. Brucellosis

7. Miscellaneous infections, including granuloma inguinale, cholera, glanders, relapsing fever and V. vulnifians. Other common uses of tetracycline (Bactocycline) include the following :

 1. Urinary Tract Infections with susceptible organisms (including the acute urethral syndrome in women).

2. Bronchitis in patients with known underlying chronic lung diseases.

3. Pelvic inflammatory disease and other sexually transmitted diseases (STDs) regimen.

4. Travelers diarrhoea.

5. Acne vulgaris

6. Prostatitis.

7. As an alternative agent in the penicillin-allergic patient with syphilis.

8. Anaerobic infections with susceptible organisms.

Dosage & Administration:

The usual adult oral dosage of Bactocycline is 1-2 g daily given in 2-4 divided doses. The usual oral dosage of Bactocycline for children older than 8 years of age in 25-50 mg/kg daily given in 2-4 divided doses. Alternatively, some clinicians recommended that children should receive 0.6-1.2 g/m2 daily.Bactocycline® should be taken preferably one hour before or 2 hours after meals. Some specific indications along with some information on dosage are given below:

 Infection Dosage and duration Remarks

Acne vulgaris 250 mg four times daily Duration of therapy is or 500 mg 12 hourly for determined by 1 week ; 125-250 mg for individual progress several weeks or months Acute 1-2 g daily in divided staphylococcal infections doses for 10-14 days Acute streptococcal 1-2 g daily in divided Prolonged therapy is infections doses for 10 days needed to avoid risk of rheumatic fever or glomerulonephritis Amoebiasis 1 g daily in four divided Given in association doses or 500 mg 12 hourly with amoebicidal for 7 days agents Brucellosis 500 mg four times daily Prolonged therapy is plus 1 g streptomycin twice necessary to avoid daily for 1 week ; then relapse 500 mg four times daily (no streptomycin) for 1 week Subacute bacterial 1-2 g daily in divided doses Usually given in endocarditis for 6 weeks combination with a bactericidal agent Syphilis Total 30-40 g given in Serology and spinal divided doses over 10-15 fluid examination days should follow the administration of tetracycline (Bactocycline).

Preparation:

Bactocycline 250 capsule: Each capsule contains Tetracycline Hydrochloride BP 250 mg.